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1

Human sweet taste receptor mediates acid-induced sweetness of miraculin

Koizumi, A., Tsuchiya, A., Nakajima, K.-i., Ito, K., Terada, T., Shimizu-Ibuka, A., Briand, L., Asakura, T., Misaka, T., Abe, K.

Journal:

Proceedings of the National Academy of Sciences

Year:

2011

Language:

english

File:

PDF, 766 KB

english, 2011

2

Microbial production of sensory-active miraculin

Keisuke Ito, Tomiko Asakura, Yuji Morita, Ken-ichiro Nakajima, Ayako Koizumi, Akiko Shimizu-Ibuka, Katsuyoshi Masuda, Masaji Ishiguro, Tohru Terada, Jun-ichi Maruyama, Katsuhiko Kitamoto, Takumi Misak

Journal:

Biochemical and Biophysical Research Communications

Year:

2007

Language:

english

File:

PDF, 229 KB

english, 2007

3

Effect of disulfide-bond introduction on the activity and stability of the extended-spectrum class A β-lactamase Toho-1

Akiko Shimizu-Ibuka, Hiroshi Matsuzawa, Hiroshi Sakai

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2006

Language:

english

File:

PDF, 409 KB

english, 2006

4

Val326 of Thermoactinomyces vulgaris R-47 amylase II modulates the preference for alpha-(1,4)- and alpha-(1,6)-glycosidic linkages

Keisuke Ito, Sohei Ito, Kousuke Ishino, Akiko Shimizu-Ibuka, Hiroshi Sakai

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2007

Language:

english

File:

PDF, 261 KB

english, 2007

5

Cysteine-to-serine shuffling using aSaccharomyces cerevisiaeexpression system improves protein secretion: case of a nonglycosylated mutant of miraculin, a taste-modifying protein

Keisuke Ito, Taishi Sugawara, Ayako Koizumi, Ken-ichiro Nakajima, Akiko Shimizu-Ibuka, Mitsunori Shiroishi, Hidetsugu Asada, Takami Yurugi-Kobayashi, Tatsuro Shimamura, Tomiko Asakura, Takumi Misaka,

Journal:

Biotechnology Letters

Year:

2011

Language:

english

File:

PDF, 312 KB

english, 2011

6

Transgenic labeling of taste receptor cells in model fish under the control of the 5′-upstream region of medaka phospholipase C-beta 2 gene

Yoshiko Aihara, Akihito Yasuoka, Yuki Yoshida, Makoto Ohmoto, Akiko Shimizu-Ibuka, Takumi Misaka, Makoto Furutani-Seiki, Ichiro Matsumoto, Keiko Abe

Journal:

Gene Expression Patterns

Year:

2007

Language:

english

File:

PDF, 1.95 MB

english, 2007

7

Bulky high-mannose-type N-glycan blocks the taste-modifying activity of miraculin

Keisuke Ito, Taishi Sugawara, Ayako Koizumi, Ken-ichiro Nakajima, Akiko Shimizu-Ibuka, Mitsunori Shiroishi, Hidetsugu Asada, Takami Yurugi-Kobayashi, Tatsuro Shimamura, Tomiko Asakura, Katsuyoshi Masu

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2010

Language:

english

File:

PDF, 1.23 MB

english, 2010

8

Crystal Structure of Neoculin: Insights into its Sweetness and Taste-modifying Activity

Akiko Shimizu-Ibuka, Yuji Morita, Tohru Terada, Tomiko Asakura, Ken-ichiro Nakajima, So Iwata, Takumi Misaka, Hiroyuki Sorimachi, Soichi Arai, Keiko Abe

Journal:

Journal of Molecular Biology

Year:

2006

Language:

english

File:

PDF, 848 KB

english, 2006

9

Crystal Structure of Mox-1, a Unique Plasmid-Mediated Class C -Lactamase with Hydrolytic Activity towards Moxalactam

Oguri, T., Furuyama, T., Okuno, T., Ishii, Y., Tateda, K., Bonomo, R. A., Shimizu-Ibuka, A.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2014

Language:

english

File:

PDF, 2.64 MB

english, 2014

10

Biochemical and Genomic Analysis of Neoculin Compared to Monocot Mannose-Binding Lectins

Shimizu-Ibuka, Akiko, Nakai, Yuji, Nakamori, Keisuke, Morita, Yuji, Nakajima, Ken-ichiro, Kadota, Koji, Watanabe, Hirohito, Okubo, Satoshi, Terada, Tohru, Asakura, Tomiko, Misaka, Takumi, Abe, Keiko

Journal:

Journal of Agricultural and Food Chemistry

Year:

2008

Language:

english

File:

PDF, 4.74 MB

english, 2008

11

An Engineered Disulfide Bond between Residues 69 and 238 in Extended-Spectrum β-Lactamase Toho-1 Reduces Its Activity toward Third-Generation Cephalosporins ‡

Shimizu-Ibuka, Akiko, Matsuzawa, Hiroshi, Sakai, Hiroshi

Journal:

Year:

2004

Language:

english

File:

PDF, 536 KB

english, 2004

12

Purification and Characterization of an α-Amylase of Pichia burtonii Isolated from the Traditional Starter “Murcha” in Nepal

TAKEUCHI, Akiko, SHIMIZU-IBUKA, Akiko, NISHIYAMA, Yoshitaka, MURA, Kiyoshi, OKADA, Sanae, TOKUE, Chiyoko, ARAI, Soichi

Journal:

Bioscience Biotechnology and Biochemistry

Year:

2006

Language:

english

File:

PDF, 129 KB

english, 2006

13

Effects of Peanut-Skin Procyanidin A1 on Degranulation of RBL-2H3 Cells

TOMOCHIKA, Keisuke, SHIMIZU-IBUKA, Akiko, TAMURA, Tomoko, MURA, Kiyoshi, ABE, Naoki, ONOSE, Jun-ichi, ARAI, Soichi

Journal:

Bioscience Biotechnology and Biochemistry

Year:

2011

Language:

english

File:

PDF, 225 KB

english, 2011

14

Novel Angiotensin I-Converting Enzyme Inhibitory Peptides Found in a Thermolysin-Treated Elastin with Antihypertensive Activity

SATO, Yuko, TOYODA, Tsudoi, SHIMIZU-IBUKA, Akiko, TAMURA, Tomoko, KOBAYASHI-HATTORI, Kazuo, NAKAMURA, Takemichi, ARAI, Soichi, MURA, Kiyoshi

Journal:

Bioscience Biotechnology and Biochemistry

Year:

2012

Language:

english

File:

PDF, 196 KB

english, 2012

15

Non-Acidic Compounds Induce the Intense Sweet Taste of Neoculin, a Taste-Modifying Protein

NAKAJIMA, Ken-ichiro, KOIZUMI, Ayako, IIZUKA, Kisho, ITO, Keisuke, MORITA, Yuji, KOIZUMI, Taichi, ASAKURA, Tomiko, SHIMIZU-IBUKA, Akiko, MISAKA, Takumi, ABE, Keiko

Journal:

Bioscience Biotechnology and Biochemistry

Year:

2011

Language:

english

File:

PDF, 143 KB

english, 2011

16

Molecular Cloning and Characterization of an α-Amylase from Pichia burtonii 15-1

KATO, Saemi, SHIMIZU-IBUKA, Akiko, MURA, Kiyoshi, TAKEUCHI, Akiko, TOKUE, Chiyoko, ARAI, Soichi

Journal:

Bioscience Biotechnology and Biochemistry

Year:

2007

Language:

english

File:

PDF, 822 KB

english, 2007

17

Hypocholesterolemic Effect of Peanut Skin and Its Fractions: A Case Record of Rats Fed on a High-Cholesterol Diet

SHIMIZU-IBUKA, Akiko, UDAGAWA, Haruhide, KOBAYASHI-HATTORI, Kazuo, MURA, Kiyoshi, TOKUE, Chiyoko, TAKITA, Toshichika, ARAI, Soichi

Journal:

Bioscience Biotechnology and Biochemistry

Year:

2009

Language:

english

File:

PDF, 64 KB

english, 2009

18

pH-Dependent Structural Change in Neoculin with Special Reference to Its Taste-Modifying Activity

MORITA, Yuji, NAKAJIMA, Ken-ichiro, IIZUKA, Kisho, TERADA, Tohru, SHIMIZU-IBUKA, Akiko, ITO, Keisuke, KOIZUMI, Ayako, ASAKURA, Tomiko, MISAKA, Takumi, ABE, Keiko

Journal:

Bioscience Biotechnology and Biochemistry

Year:

2009

Language:

english

File:

PDF, 115 KB

english, 2009

19

Serum Cholesterol Reduction by Feeding a High-Cholesterol Diet Containing a Lower-Molecular-Weight Polyphenol Fraction from Peanut Skin

TAMURA, Tomoko, INOUE, Naoko, SHIMIZU-IBUKA, Akiko, TADAISHI, Miki, TAKITA, Toshichika, ARAI, Soichi, MURA, Kiyoshi

Journal:

Bioscience Biotechnology and Biochemistry

Year:

2012

Language:

english

File:

PDF, 99 KB

english, 2012

20

Peanut-Skin Polyphenols, Procyanidin A1 and Epicatechin-(4 β→6)-epicatechin-(2 β→ O →7, 4 β→8)-catechin, Exert Cholesterol Micelle-Degrading Activity in Vitro

TAMURA, Tomoko, INOUE, Naoko, OZAWA, Megumi, SHIMIZU-IBUKA, Akiko, ARAI, Soichi, ABE, Naoki, KOSHINO, Hiroyuki, MURA, Kiyoshi

Journal:

Bioscience Biotechnology and Biochemistry

Year:

2013

Language:

english

File:

PDF, 179 KB

english, 2013

21

Crystal Structure of Pyruvate Kinase from Geobacillus stearothermophilus

Suzuki, K., Ito, S., Shimizu-Ibuka, A., Sakai, H.

Journal:

Journal of Biochemistry

Year:

2008

Language:

english

File:

PDF, 755 KB

english, 2008

22

Roles of Residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in Extended-Spectrum -Lactamase Toho-1

Shimizu-Ibuka, A., Oishi, M., Yamada, S., Ishii, Y., Mura, K., Sakai, H., Matsuzawa, H.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2011

Language:

english

File:

PDF, 885 KB

english, 2011

23

Purification, crystallization and preliminary X-ray analysis of IMP-18, a class B carbapenemase from Pseudomonas aeruginosa

Furuyama, Takamitsu, Ishii, Yoshikazu, Ohya, Norimasa, Tateda, Kazuhiro, Hanson, Nancy D., Shimizu-Ibuka, Akiko

Journal:

Acta Crystallographica Section F Structural Biology and Crystallization Communications

Year:

2013

Language:

english

File:

PDF, 329 KB

english, 2013

24

Acid-induced sweetness of neoculin is ascribed to its pH-dependent agonistic-antagonistic interaction with human sweet taste receptor

Nakajima, K.-i., Morita, Y., Koizumi, A., Asakura, T., Terada, T., Ito, K., Shimizu-Ibuka, A., Maruyama, J.-i., Kitamoto, K., Misaka, T., Abe, K.

Journal:

The FASEB Journal

Year:

2008

Language:

english

File:

PDF, 648 KB

english, 2008

25

Extracellular Production of Neoculin, a Sweet-Tasting Heterodimeric Protein with Taste-Modifying Activity, by Aspergillus oryzae

Nakajima, K.-i., Asakura, T., Maruyama, J.-i., Morita, Y., Oike, H., Shimizu-Ibuka, A., Misaka, T., Sorimachi, H., Arai, S., Kitamoto, K., Abe, K.

Journal:

Applied and Environmental Microbiology

Year:

2006

Language:

english

File:

PDF, 284 KB

english, 2006

26

Conformational Change Observed in the Active Site of Class C β-Lactamase MOX-1 upon Binding to Aztreonam

Oguri, Takuma, Ishii, Yoshikazu, Shimizu-Ibuka, Akiko

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2015

Language:

english

File:

PDF, 873 KB

english, 2015

27

Neoculin, a taste-modifying protein, is recognized by human sweet taste receptor

Nakajima, Ken-ichiro, Asakura, Tomiko, Oike, Hideaki, Morita, Yuji, Shimizu-Ibuka, Akiko, Misaka, Takumi, Sorimachi, Hiroyuki, Arai, Soichi, Abe, Keiko

Journal:

Year:

2006

Language:

english

File:

PDF, 105 KB

english, 2006

28

Structural and Mutagenic Analysis of Metallo-β-lactamase IMP-18

Furuyama, Takamitsu, Nonomura, Haruka, Ishii, Yoshikazu, Hanson, Nancy D., Shimizu-Ibuka, Akiko

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2016

Language:

english

File:

PDF, 4.90 MB

english, 2016

29

Identification of key neoculin residues responsible for the binding and activation of the sweet taste receptor

Koizumi, Taichi, Terada, Tohru, Nakajima, Ken-ichiro, Kojima, Masaki, Koshiba, Seizo, Matsumura, Yoshitaka, Kaneda, Kohei, Asakura, Tomiko, Shimizu-Ibuka, Akiko, Abe, Keiko, Misaka, Takumi

Journal:

Scientific Reports

Year:

2015

Language:

english

File:

PDF, 1.61 MB

english, 2015

30

Identification and Modulation of the Key Amino Acid Residue Responsible for the pH Sensitivity of Neoculin, a Taste-Modifying Protein

Nakajima, Ken-ichiro, Yokoyama, Kanako, Koizumi, Taichi, Koizumi, Ayako, Asakura, Tomiko, Terada, Tohru, Masuda, Katsuyoshi, Ito, Keisuke, Shimizu-Ibuka, Akiko, Misaka, Takumi, Abe, Keiko, Koch, Karl-

Journal:

Year:

2011

Language:

english

File:

PDF, 585 KB

english, 2011

31

Structural and functional analysis of miraculin-like protein from Vitis vinifera

Ohkura, So-ichiro, Hori, Misaho, Saitoh, Kazuki, Okuzawa, Takumi, Okamoto, Ikuko, Furukawa, Nayuta, Shimizu-Ibuka, Akiko

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2018

Language:

english

File:

PDF, 1.93 MB

english, 2018

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